The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development

The Bitter Side of Sugar Consumption: A Mitochondrial Perspective on Diabetes Development

Blog Article

Type 2 diabetes (T2D) has increased worldwide at an alarming rate.Metabolic syndrome (MetS) is a major risk factor for T2D development.One of the main reasons for the abrupt rise in MetS incidence, besides a sedentary lifestyle, is the westernized diet consumption, with high content of industrialized foods, rich radio birdman tshirt in added dietary sugars (DS), mainly sucrose and fructose.It has been suggested that a higher intake of DS could impair metabolic function, inducing MetS, and predisposing to T2D.

However, it remains poorly explored how excessive DS intake modulates mitochondrial function, a key player in metabolism.This review explores the relationship between increased consumption of DS and mitochondrial dysfunction associated with T2D development, pointing to a contribution of the diet-induced click here accumulation of advanced glycation end-products (AGEs), with brief insights on the impact of maternal high-sugar diet and AGEs consumption during gestation on offspring increased risk of developing T2D later in life, contributing to perpetuate T2D propagation.